This fully-resourced lesson uses the lac operon as an example to describe how gene expression is regulated and controls cell processes and structures. The detailed PowerPoint and accompanying resources have been designed to cover the details of specification point 3.12 of the Pearson Edexcel A-level Biology A course.
This is one of the more difficult concepts in this A-level course and therefore key points are reiterated throughout this lesson to increase the likelihood of student understanding and to support them when trying to make links to actual biological examples in living organisms. There is a clear connection to transcription and translation as covered in topic 2, so the lesson begins by reminding students that in addition to the structural gene in a transcription unit, there is the promotor region where RNA polymerase binds. Students are introduced to the idea of transcription factors and will understand how these molecules can activate or repress transcription by enabling or preventing the binding of the enzyme. At this point, students are challenged on their current understanding with a series of questions about DELLA proteins so they can see how these molecules prevent the binding of RNA polymerase. The main section of the lesson focuses on the lac operon. Students will be able to visualise the different structures that are found in this unit of DNA and time is taken to go through the individual functions. A step by step guide is used to walk students through the sequence of events that occur when lactose is absent and when it is present before they are challenged to apply their understanding to an exam question. The final section of the lesson looks at one further example with oestrogen and the ER receptor.
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Nucleic acids, Genetics and Inheritance (Edexcel SNAB)
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Another excellent resource that keeps the students engaged. Thanks again.
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