Peptide Bond Modelling – Molecular Modelling Activity

Description:
This hands-on molecular modeling activity helps students understand the fundamental process of peptide bond formation between amino acids. Using a molecular model kit, students construct glycine and alanine, simulate a condensation reaction, and visualize the formation of a peptide bond while identifying water as a byproduct.

Activity Overview:
Build molecular models of glycine and alanine using a molecular model kit.
Simulate a peptide bond formation by removing the necessary atoms and forming a new bond.
Document the process with photographs and analyze the reaction.
Summarize key takeaways about amino acid bonding and the biochemical significance of condensation reactions.

Apparatus Required:
Molecular model kit (containing black, red, white, and blue balls for different atoms).
Smartphone or digital camera for documentation.

Learning Outcomes:
Identify the structure of amino acids.
Demonstrate peptide bond formation through molecular modeling.
Understand the role of condensation reactions in protein synthesis.

This engaging activity enhances conceptual understanding and visualization of biochemical reactions, making it a great resource for biology classrooms.