This fully-resourced lesson describes the regulatory mechanisms that control gene expression at a transcriptional level. The detailed PowerPoint and accompanying resources have been designed to cover the first part of point 6.1.1 (b) as detailed in the OCR A-level Biology A specification which states that the students knowledge should include the lac operon and examples of transcription factors in eukaryotes. . This is one of the more difficult concepts in this A-level course and therefore key points are reiterated throughout this lesson to increase the likelihood of student understanding and to support them when trying to make links to actual biological examples in living organisms. There is a clear connection to transcription and translation as covered in module 2.1.3, so the lesson begins by reminding students that in addition to the structural gene in a transcription unit, there is the promotor region where RNA polymerase binds. Students are introduced to the idea of transcription factors and will understand how these molecules can activate or repress transcription by enabling or preventing the binding of the enzyme. At this point, students are challenged on their current understanding with a series of questions about DELLA proteins so they can see how these molecules prevent the binding of RNA polymerase. Their understanding is then tested again with another example with oestrogen and the ER receptor. The final and main section of the lesson focuses on the lac operon and immediately an opportunity is taken to challenge their knowledge of biological molecules with a task where they have to spot the errors in a passage describing the formation and breakdown of this disaccharide. Students will be able to visualise the different structures that are found in this operon and time is taken to go through the individual functions. A step by step guide is used to walk students through the sequence of events that occur when lactose is absent and when it is present before they are challenged to apply their understanding to an exam question.

This fully-resourced lesson looks at the effects of nervous mechanisms on the heart rate. The engaging and detailed PowerPoint and accompanying resources have been designed to cover the part of point 5.1.5 (k) of the OCR A-level Biology A specification which states that students should be able to demonstrate and apply their knowledge and understanding of the control of the heart rate by the cardiovascular centre in the medulla oblongata This lesson begins with a prior knowledge check where students have to identify and correct any errors in a passage about the conduction system of the heart. This allows the SAN to be recalled as this structure play an important role as the effector in this control system. Moving forwards, the three key parts of a control system are recalled as the next part of the lesson will specifically look at the range of sensory receptors, the coordination centre and the effector. Students are introduced to chemoreceptors and baroreceptors and time is taken to ensure that the understanding of the stimuli detected by these receptors is complete and that they recognise the result is the conduction of an impulse along a neurone to the brain. A quick quiz is used to introduce the medulla oblongata as the location of the cardiovascular centre. The communication between this centre and the SAN through the autonomic nervous system can be poorly understood so detailed explanations are provided and the sympathetic and parasympathetic divisions compared. The final task challenges the students to demonstrate and apply their understanding by writing a detailed description of the control and this task has been differentiated three ways to allow differing abilities to access the work

An engaging lesson presentation (33 slides) and associated worksheets that introduces students to classification using the taxonomic levels and teaches them how to name species using the binomial naming system. The students are told about the domain system, as developed by Carl Woese, but then the lesson focuses on showing them the seven levels that come after this. Students are challenged to understand how the levels differ from each other in terms of sharing characteristics. Time is taken to focus on the five kingdoms and links are made to other topics such as prokaryotic cells to test their previous knowledge. Moving forwards, students are shown how the genus and species are used in the binomial naming system before being given lots of opportunities to assess their understanding through questions. This lesson has been written for GCSE students but is suitable for all age ranges

This lesson describes how genetic diversity within, or between species, can be investigated by comparison of characteristics or biological molecules. The PowerPoint and accompanying worksheets are primarily designed to cover the content of point 4.7 of the AQA A-level Biology specification but as this is the last lesson in the topic, it has also been planned to contain a range of questions, tasks and quiz rounds that will challenge the students on their knowledge and understanding of topic 4. Over the course of the lesson, the students will discover that comparisons of measurable or observable characteristics, DNA and mRNA sequences and the primary structure of common proteins can all be used to investigate diversity. Links are continually made to prior learning, such as the existence of convergent evolution as evidence of the need to compare biological molecules as opposed to the simple comparison of phenotypes. The issues associated with a limited genetic diversity are discussed and the interesting biological example of the congenital dysfunctions consistently found in the Sumatran tigers in captivity in Australia and New Zealand is used to demonstrate the problems of a small gene pool. Moving forwards, the study of the 16S ribosomal RNA gene by Carl Woese is introduced and students will learn that this led to the adoption of the three-domain system in 1990. The final part of the lesson describes how the primary structure of proteins like cytochrome c that is involved in respiration and is therefore found in most living organisms can be compared and challenges the students to demonstrate their understanding of protein synthesis when considering the differences between humans and rhesus monkeys.

A highly engaging lesson that looks at the structures that are found in the 1st line of defence and explores the methods of action use by phagocytes and lymphocytes. This lesson has been designed for GCSE students but could be used as an initial recap with A-level students before they go on to learn this topic in greater detail The lesson begins by introducing the meaning of the 1st line of defence. A quick competition is used to challenge the students to recognise the names of some of these structures when their names have some letters missing. Time is taken to discuss the action of the cilia and skin and then students are challenged to make links to the related topics of enzymes and pH as they complete a passage about the role of hydrochloric acid in the stomach. Moving forwards, students will learn that there are two types of white blood cells, phagocytes and lymphocytes, and the details of their actions is explored. Key points such as the specificity of antibodies and the involvement of enzymes are discussed in detail so that this topic can be understood to the depth needed at this level. In addition to a number of games to maintain engagement, progress checks are written into this at regular intervals to allow the students to assess their understanding.

This fully-resourced REVISION LESSON has been designed to provide the students with numerous opportunities to assess their understanding of the content of module 5.2.2 (Respiration) of the OCR A-level Biology A specification. The importance of this metabolic reaction is obvious and this is reflected in the volume of questions in the terminal exams which require an in depth knowledge of the stages of both aerobic and anaerobic respiration. The lesson contains a wide range of activities that cover the following points of the specification: Glycolysis as a stage of aerobic and anaerobic respiration The use and production of ATP through respiration Anaerobic respiration in mammalian muscle tissue The stages of aerobic respiration that occur in the mitochondrial matrix Oxidative phosphorylation The use of respirometers Calculating the respiratory quotient value for different respiratory substrates Revision lessons which cover the other sub-modules of module 5 are uploaded and tie in well with this content

This is a fully-resourced lesson that looks at the functional and structural differences between the transport tissues in a plant, the xylem and phloem. The lesson includes an engaging lesson presentation (41 slides), which includes numerous student-led tasks, progress checks and quick competitions and two question worksheets, one of which is a differentiated version to enable those students who are finding this topic difficult to still be able to access the learning. The lesson begins with the introduction of the two tissues as well as a brief introduction to the substances which they each carry. The next part of the lesson focuses on the xylem cells and the resulting xylem vessel, and key terms such as lignin are brought into the lesson so that students can understand how these cells are waterproofed, which causes them to decay and form hollow tubes. Having met a lot of information, students are challenged to act like an examiner to form a table based question to compare the xylem against the phloem where they have to come up with features which could be compared against. This table will form the backbone of the lesson and students will use it later in the lesson when they have to write summary passages about each of the tissues. Moving forwards, a quick competition is used to enable the students to meet the names of the cells that form the phloem tissue, the sieve tube elements and the companion cells. Students will see how they are involved in the functioning of the phloem and questions are posed which relate to other topics such as the involvement of mitochondria wherever active transport occurs. Progress checks like this are found at regular intervals throughout the lesson so that students can constantly assess their understanding. This lesson has been designed for GCSE students. If you are looking to teach about these tissues but to a higher standard, you could use my uploaded alternative called Xylem and Phloem (A-level)

This fully-resourced lesson focuses on the events of meiosis which specifically contribute to genetic variation. The detailed PowerPoint and accompanying resources have been designed to cover the 4th and final part of point 4.3 of the AQA A-level Biology specification which states that students should be able to describe how meiosis produces daughter cells that are genetically different from each other. In order to understand how the events of meiosis like crossing over and random assortment and independent segregation can lead to variation, students need to be clear in their understanding that DNA replication in interphase results in homologous chromosomes as pairs of sister chromatids. Therefore the beginning of the lesson focuses on the chromosomes in the parent cell and this first part of the cycle and students will be introduced to non-sister chromatids and the fact that they may contain different alleles which is important for the exchange that occurs during crossing over. Time is taken to go through this event in prophase I in a step by step guide so that the students can recognise that the result can be new combinations of alleles that were not present in the parent cell. Moving forwards, the lesson explores how the independent segregation of chromosomes and chromatids during anaphase I and II results in genetically different gametes. The final part of the lesson looks at the use of a mathematical expression to calculate the possible combinations of alleles in gametes as well as in a zygote following the random fertilisation of haploid gametes. Understanding and prior knowledge checks are interspersed throughout the lesson as well as a series of exam questions which challenge the students to apply their knowledge to potentially unfamiliar situations. Due to the detail of this lesson, it is estimated that this will take about 2 hours of A-level teaching time to deliver

This is a fully-resourced revision resource which has been designed to encourage students to evaluate their understanding of the content in TOPIC 4 of the AQA A-level Biology specification (Genetic information, variation and relationships between organisms) . The resource includes an engaging PowerPoint (96 slides) and associated worksheets, some of which have been differentiated to allow those struggling with the content to access the work. The wide range of activities which includes exam questions, quick tasks and quiz competitions will motivate the students whilst they assess their knowledge and recognise those areas which require even further attention. The lesson has been designed to cover as many sub-topics as possible but the following have been given particular attention: Classification hierarchy DNA in prokaryotes and eukaryotes The binomial naming system Phylogeny Modern day classification using biological molecules Calculating biodiversity Selection pressures and types of selections Transcription Gene mutations Physiological, behavioural and anatomical adaptations Meiosis and variation Non-disjunction The mathematical element of this topic and the course is challenged throughout the lesson and helpful hints are regularly provided to help students to structure their answers. This resource can be used as a revision aid at the end of the topic, in the lead up to AS or A2 mocks or in the lead up to the actual terminal A-level exams.

An engaging lesson presentation (75 slides) and associated worksheets that uses a combination of exam questions, quick tasks and quiz competitions to help the students to assess their understanding of the topics found within unit B7(Ecology) of the AQA GCSE Biology specification (specification unit B4.7). The topics that are tested within the lesson include: Communities Abiotic factors Biotic factors Levels of organisation Recycling materials Decomposition Deforestation Global warming Trophic levels Pyramids of biomass Transfer of biomass Students will be engaged through the numerous activities including quiz rounds like “Number CRAZY" whilst crucially being able to recognise those areas which need further attention

This fully-resourced lesson describes the behaviour of chromosomes during interphase, mitosis and cytokinesis in the cell cycle. The detailed PowerPoint and accompanying resources have been designed to cover the first half of point 2.2 as detailed in the AQA A-level Biology specification whereas uncontrolled cell division and cancer and binary fission are covered in upcoming lessons. Depending upon the exam board taken at GCSE, the knowledge and understanding of mitosis and the cell cycle will differ considerably between students and there may be a number of misconceptions. This was considered at all points during the planning of the lesson and to address existing errors, key points are emphasised throughout. The cell cycle is introduced at the start of the lesson and the quantity of DNA inside the parent cell is described as diploid and as 2n. A quiz competition has been written into the lesson and this runs throughout, challenging the students to identify the quantity of DNA in the cell (in terms of n) at different points of the cycle. Moving forwards, the first real focus is interphase and the importance of DNA replication is explained so that students can initially recognise that there are pairs of identical sister chromatids and then can understand how they are separated later in the cycle. The main part of the lesson focuses on prophase, metaphase, anaphase and telophase and describes how the chromosomes behave in these stages. Centrioles were not covered in the topic 2.1 lessons on cell structures so a quick task will introduce them to these organelles who are responsible for the production of the spindle apparatus, Students will understand how the cytoplasmic division that occurs in cytokinesis results in the production of genetically identical daughter cells. This leads into a series of understanding and application questions where students have to identify the various roles of mitosis in living organisms as well as tackling a Maths in a Biology context question. The lesson concludes with a final round of MITOSIS SNAP where they only shout out this word when a match is seen between the name of a phase, an event and a picture.

This lesson describes the uses and implications of pre-implantation genetic diagnosis, amniocentesis and chorionic villus sampling. The lesson PowerPoint and accompanying worksheets have been primarily designed to cover point 2.15 of the Pearson Edexcel A-level Biology A (Salters Nuffield) specification but regular links are made to the earlier content of topics 1 & 2, and their knowledge of topics including the heart and circulation, monohybrid inheritance and cystic fibrosis are tested. The lesson begins by challenging them to use this prior knowledge of topic 2 to identify the letters in the abbreviations PGD and CVS. The involvement of IVF to obtain the embryos (or oocytes) is then discussed and a series of exam-style questions are used to get them to understand how this method screens embryos prior to implantation, so that those identified as having genetic diseases or being carriers are not inserted into the female’s uterus. Mark schemes for all of the questions included in this lesson are embedded into the PowerPoint so students can constantly assess their progress. Moving forwards, Down syndrome (trisomy 21) is used as an example of a chromosomal abnormality that can be tested for using CVS or amniocentesis. Time is taken to describe the key details of both of these procedures so students have a clear understanding of the implications and the invasiveness to the female being tested. The link between amniocentesis and an increased risk of miscarriage is considered and the results of a 2006 study are used to challenge them on their data skills.

This lesson looks at the use of the polymerase chain reaction (PCR) as an in vitro method to amplify DNA fragments as part of the recombinant DNA technology process. The clear PowerPoint has been designed to cover the second part of point 8.4.1 of the AQA A-level Biology specification. A quick quiz competition is used to introduce the PCR abbreviation before students are encouraged to discuss the identity of the enzyme involved and to recall the action of this enzyme. Students will learn that this reaction involves cyclical heating and cooling to a range of temperatures so the next part of this lesson looks at these particular temperatures so the important parts of each of the steps can be understood. Time is taken to examine the key points in detail, such as the specific DNA polymerase that is used and how it is not denatured at the high temperature as well as the involvement of the primers.

An engaging lesson presentation and associated worksheet that looks at the use of antibiotics to treat bacterial infections and the raises the issue of the potential over-use of these substances. The lesson begins by getting the students to recognise the difference between three key terms that begin with anti (antibiotics, antivirals, antiseptics). Students will be introduced to the idea that antibiotics are specific to a small range of bacteria and therefore the correct one has to be selected before being prescribed. Moving forwards, students will meet the idea of the zone of inhibition and will understand how the size of this zone can be used as an indicator to the effectiveness of the treatment. Students are shown how to calculate the size of the zone and then are tested on their ability to apply this mathemetical knowledge. Finally, time is taken to look at the links to the topic of natural selection to explain how some bacteria are resistant to certain antibiotics. There are regular progress checks throughout the lesson so that students can assess their understanding. This lesson has been designed for GCSE students but could be used as an introduction with A-level Biology students who are about to begin the topic of immunity.

This fully-resourced lesson describes how antibodies are used in the enzyme-linked immunosorbent assay (ELISA) test. The PowerPoint and accompanying resources are part of the last lesson in a series of 7 which have been designed to cover the details within point 2.4 of the AQA A-level specification. As the last lesson in this sub-topic, prior knowledge checks are included throughout the lesson which challenge the students on their knowledge of antibodies, immunity and protein structure. The lesson begins by challenging the students to use the details of a poster to recognise that individuals who have recovered from COVID-19 could donate plasma and the antibodies be infused into newly infected individuals. They are then expected to answer a series of exam-style questions where they have to describe the structure of these specific antibodies, recognise this as artificial, passive immunity and describe the potential problems should the virus mutate and the shape of its antigens change. This leads into the introduction of the use of antibodies in other ways, namely the ELISA test. The methodology of this test has been divided into four key steps which students will consider one at a time and then answer further questions about key details such as the immobilisation of the antigen and the removal of proteins and antibodies that have not bound by the washing with the detergent after each step. The lesson focuses on the use of this test for medical diagnosis but other uses such as plant pathology and the detection of allergens is briefly introduced at the end of the lesson.

This lesson describes the structure and ultrastructure of plant cells to allow students to compare this structure against animal cell structure. The detailed PowerPoint and accompanying resources have been designed to cover points 4.1 (i) & (ii) in unit 2 of the Edexcel International A-level Biology specification and also describes the functions of the cell wall, chloroplast, amyloplast, vacuole, tonoplast, plasmodesmata, pits and middle lamella The lesson begins with a task called REVERSE GUESS WHO which will challenge the students to recognise a particular organelle from a description of its function. This will remind students that plant cells are eukaryotic and therefore contain a cell-surface membrane, a nucleus (+ nucleolus), a mitochondria, a Golgi apparatus, ribosomes and rough and smooth endoplasmic reticulum like the animal cells. Moving forwards, the next part of the lesson focuses on the relationship between the structure and function of the vacuole, chloroplast, plasmodesmata and cellulose cell wall. When considering the vacuole, key structures such as the tonoplast are described as well as critical functions including the maintenance of turgor pressure. A detailed knowledge of the structure of the chloroplast at this early stage of their A-level studies will increase the likelihood of a clear understanding of photosynthesis when covered in topic 5. For this reason, time is taken to consider the light-dependent and light-independent reactions and to explain how these stages are linked. Students will learn that chloroplasts and amyloplasts can contain stores of starch so an opportunity is taken to challenge them on their knowledge of this polysaccharide as it was covered in topic 1. The final task challenges them to recognise descriptions of the cell wall, chloroplast, amyloplasts, vacuole, tonoplast and plasmodesmata which will leave 2 remaining which describe the pits and middle lamella.